Calcium Carboxy Methyl Cellulose
Carmellose calcium is a white or creamish white in colour and chemically it is calcium salt of carboxy methyl cellulose with very high degree of purity. Very hard tablets where other superdisintegrants do not perform well, carmellose calcium perform s very much satisfactory. Quantity to be used in pharmaceutical formulation is very less. Carmellose calcium helps in dissolution of drugs having poor solubility.
CARBOXY METHYL CELLULOSE CALCIUM |
|
PROPERTY |
SPECIFICATION |
Description |
White to yellowish white hygroscopic odourless powder |
Identification |
Pass A,B,C,D of USP, BP, Ph.Eur |
Alakalanity |
No pink colour developed on addition of phenolphthalein |
Loss on Drying |
Max 10 % |
Sulphated Ash @ 600 C |
10 TO 20 % |
Residual Solvents |
Should be Complies as per USP <467 |
Organic Volatile Impurities |
Should be complies USP |
Heavy Metals |
Less than 20 ppm |
Sulphates |
1% BP/PhEur 0.96 % |
Silicates |
0.6% BP/PhEur 1.5% USP |
Starch |
No blue colour with lodine |
Total Aerobic Microbial Count |
Less than 1000 c fu /gm |
Total yeast &muold count |
Less than 100 c fu/gm |
Pathogens (E Coli, pseudomonas, aeruginosa, staphylococcus aureus, salmonella) |
Absent |